Airport runway design?

When airport runways are built, I notice that two runways are usually laid out in a cross pattern. Do the designers lay out the runways based on the typical prevailing winds in the area for the aircraft takeoff and landings?
And if so, what happens if the winds are coming in a direction which is not compatible with the runway layout? Can aircraft still land?

Other answer:

Traveler:
airport runways are laid out in accordance with the prevailing winds, with an eye to the local terrain.

around here (southwestern british columbia) almost every airport has an east-west runway, reflecting the prevailing westerly winds. at my home airport the runways are 07/25 and 12/30. it was originally an air base in ww2 and was built as a triangle, though one of the original runways is now an apron for aircraft parking. another local airport is in a valley and has a single runway 16/34, because that's all that fits.

crosswind landings are fun. in some planes the crosswind is an operating limitation (exceed the crosswind and the flight is illegal), while in others it's demonstrated, i.e. a test pilot was able to land the plane in that crosswind.

FanMan:
When possible, runways are laid out according to the prevailing winds. However, in many cases the runway arrangement is dictated by the size, shape, or terrain of the airport property. The airport I fly out of has only one runway, which is usually crosswind… the airport is on a ridge and the runway runs along the ridge; there wouldn't be room to orient it any other way.
Bell:
Yes whenever spaces permits, the runways are angled into the usual wind directions.
Graham:
Yes whenever spaces permits, the runways are angled into the usual wind directions.
Tim:
Yes whenever spaces permits, the runways are angled into the usual wind directions.
Bertsta:
Yes whenever spaces permits, the runways are angled into the usual wind directions.
Timbo is here:
Yes
Skipper747:
Airplanes can handle some amount of crosswind –
It is called "demonstrated crosswind" in the limitations of the airplane flight manual –

The 747 airliner as example can takeoff or land with a crosswind blowing at speed of 29 knots –
The crosswind "angle" can be as much as 90ยบ –
.

STEPHEN:
You've heard of a crosswind landing?
talbot:
You've heard of a crosswind landing?

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